What is Parkinson's Disease?
The onset of Parkinson's disease is a tragic time for any patient and their families. As a degenerative condition, patients suffering from the condition are faced with no hope of recovery, but rather a slow and wearing process of loss of movement and co-ordination. Most notably, the condition involves the tremor, whereby patients can be seen trembling uncontrollably, as well as loss in speech capabilities and gradually all functionality in its later stages.
Parkinson's disease is a disorder which takes effect on the central nervous system. A movement disorder, Parkinson's can be seen in four major symptoms; namely rigidity of muscles, a tremor of movement, slowing of overall movement (known as bradykinesia) and in certain instances loss of movement altogether. The symptoms gradually become more and more apparent in sufferers, and are progressive, that is patients do not recover, or get better. This degenerative condition is not contagious, nor passed genetically, and very little is known about the causes of most instances of the condition. Having said that, some cases can be explained through extreme drug abuse, cranial damage and other abuses of the body which have been shown to give rise to the condition.
The condition occurs as a result of the loss or destruction of brain cells which produce dopamine, a chemical associated with muscle activity. This chronic condition was first discovered and charted by James Parkinson in 1817, and concerns what he labelled as his patient's 'shaking palsy'.
A disease which has been a mystery to scientists and physicians across the world since its discovery, Parkinson's has no known cure, although there are ways to treat it and perhaps stall its development. Additionally, there are a number of support groups for both sufferers and carers, providing some much needed reassurance that all is not lost, and there are still ways to work to help the condition, which can sometimes feel like a distant fantasy.
A particularly crushing aspect of the disease is the impact it can have on a patient's everyday life. The simplest of physical tasks become impossible, leaving the sufferer eventually in need of round the clock care and attention. There is a present no way of knowing who will develop the disease, or to what extent, although reassuringly, scientists the world over are desperately trying to expand their knowledge of the condition and look for other treatments, and possibly even the elusive cure.
Sadly, for patients with Parkinson's today, there is no real way out, and it's best to try and remain as active and involved as possible in the normal daily routine to keep up morale, and keep the patient interested in life. Such a demoralising condition as Parkinson's requires a lot of patience, and it can be particularly hard and frustrating to see a family member descend into such a state. There are however, a variety of ways to significantly reduce the effects of the condition, and it is advisable for anyone worried about themselves or friend or family member to consult their physician for more information on the condition and what can be done to curb its onset.
Parkinson's disease news on the Web
Gene Therapy Helps Children With Rare, Incurable Brain Disease
Using gene transfer techniques pioneered by University of Florida faculty, Taiwanese doctors have restored some movement in four children bedridden with a rare, life-threatening neurological disease. The first-in-humans achievement may also be helpful for more common diseases such as Parkinson's that involve nerve cell damage caused by lack of a crucial molecule in brain tissue... |
Unravelling How Locomotion Starts
Scientists at the University of Bristol have shed new light on one of the great unanswered questions of neuroscience: how the brain initiates rhythmic movements like walking, running and swimming... |
Potential To Predict Parkinson's Disease Via Colonoscopy Or Flexible Sigmoidoscopy
Two studies by neurological researchers at Rush University Medical Center suggest that, in the future, colonic tissue obtained during either colonoscopy or flexible sigmoidoscopy may be used to predict who will develop Parkinson's disease, a neurodegenerative disorder of aging that that leads to progressive deterioration of motor function due to loss of neurons in the brain tha... |
Damaged Stem Cells Commit Suicide For The Good Of The Embryo
Embryonic stem cells - those revered cells that give rise to every cell type in the body - just got another badge of honor. If they suffer damage that makes them a threat to the developing embryo, they swiftly fall on their swords for the greater good, according to a study published online in the journal Molecular Cell... |
Once-Marginalized Parkinson's Disease Theory May Be Valid
The March issue of the FEBS Journal reports that scientists from the Californian University in San Diego have discovered new evidence for a theory that was once marginalized with regard to the underlying causes of Parkinson's disease, which conflicts with an older theory that Parkinson's and other neurodegenerative diseases are caused by insoluble intracellular fibrils called amyloids... |
Strong Support Uncovered For Once-Marginalized Theory On Parkinson's Disease
University of California, San Diego scientists have used powerful computational tools and laboratory tests to discover new support for a once-marginalized theory about the underlying cause of Parkinson's disease. The new results conflict with an older theory that insoluble intracellular fibrils called amyloids cause Parkinson's disease and other neurodegenerative diseases... |
Parkinson's Patients Might Respond To 19th Century Vibration-Chair Therapy
To relieve symptoms of Parkinson's disease, Jean-Martin Charcot, a famous neurologist in the 19th century developed a "vibration chair" that showed improvements in his patients. However, Charcot died soon afterwards, before being able to conduct a more comprehensive evaluation of his therapy... |
Parkinson's Protein Causes Disease Spread In Animal Model
Last year, researchers from the Perelman School of Medicine at the University of Pennsylvania found that small amounts of a misfolded brain protein can be taken up by healthy neurons, replicating within them to cause neurodegeneration... |
Understanding How Parkinson's Disease Starts And Spreads
Injection of a small amount of clumped protein triggers a cascade of events leading to a Parkinson's-like disease in mice, according to an article published online this week in the Journal of Experimental Medicine. Progressive accumulation of clumps of the protein alpha-synuclein in the brains of patients with Parkinson's disease coincides with the onset of motor dysfunction... |
Easing Depression In Parkinson's Patients Without Worsening Other Symptoms
Today's anti-depressant medications can ease depression in Parkinson's patients without worsening other symptoms of the disease, according to a study published online in Neurology®, the medical journal of the American Academy of Neurology. "Depression is the number-one factor negatively affecting the quality of life for people with Parkinson's disease," said Irene Hegeman Richard, M.D... |
Ocular Tremors Parkinson's Disease Link
A study, published Online First by Archives of Neurology, reveals that persistent eye tremors seem to be common in individuals suffering from Parkinson's disease (PD). Ocular tremors can prevent eye stability during fixation and results from the study indicate that precise oculomotor testing could provide an early physiological biomarker for diagnosing Parkinson's disease. George T... |
Eating Berries May Lower Men's Parkinson's Risk
Men who regularly consume foods rich in flavonoids, such as berries, apples, certain vegetables, tea and red wine, may significantly reduce their risk for developing Parkinson's disease, according to a study published in the journal Neurology this week that saw no such effect among women... |
Potential Strategy To Restore Motor And Cognitive Function In Parkinson's Disease
An agent under consideration for use in PET imaging combats neuronal death to relieve Parkinsonian symptoms in animal models, according to a study published in the Journal of Experimental Medicine. The movement-related symptoms of Parkinson's disease, including muscle rigidity and tremors, are caused by the loss of dopamine-secreting neurons in the brain... |
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